2. Neurological Disease

Neurological Disease

Neurological Disease

Related Products

PDF 88.0 MB

A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P11314
    ABri 241145-90-4
    ABri, 34 amino acids long, is an Amyloid subunit with certain degree of N- and C-terminal heterogeneity and no sequence identity to any known amyloid protein. ABri is devoid of glycine, methionine, proline, aspartic acid, tryptophane, tyrosine and glutamine, featuring pyroglutamate at its N-terminus. ABri can be used for cerebral hemorrhages, ischemic infarction and Alzheimer disease research.
    ABri
  • HY-P11319
    RAP-103 1337998-99-8 98%
    RAP-103 is an orally active CCR antagonist that provides potent synaptic protection by inhibiting and reversing cytoskeletal changes induced by PrPC/NOX signaling. RAP-103 is potentially useful in Alzheimer's disease (AD) research.
    RAP-103
  • HY-P11322
    NHIP peptide 2912290-24-3 98%
    NHIP peptide is a peptide segment containing 20 amino acids located in the nucleus of the cell. NHIP is highly expressed in neuronal derived cells such as LUHMES cells. NHIP peptide can promote the proliferation of 293T cells. NHIP peptide regulates gene networks related to neural development and autism spectrum disorder (ASD).
    NHIP peptide
  • HY-P11326
    Ac-FR-AFC TFA 99.51%
    Ac-FR-AFC TFA is a fluorometric substrate for cathepsin L. Ac-FR-AFC TFA can be used for the research of glioblastoma.
    Ac-FR-AFC TFA
  • HY-P1135A
    M1145 TFA 98%
    M1145 TFA, a chimeric peptide, is a selective galanin receptor type 2 (GAL2) agonist, with a Ki of 6.55 nM. M1145 TFA shows more than 90-fold higher affinity for GAL2 over GAL1 (Ki=587 nM) and a 76-fold higher affinity over GalR3 (Ki=497 nM). M1145 TFA has an additive effect on the signal transduction of galanin.
    M1145 TFA
  • HY-P11380
    Capa-2 454186-80-2 98%
    Capa-2 is a neuropeptide. Capa-2 activates calcium ion influx, stimulates the production of NO, activates soluble guanylate cyclase (sGC), increases intracellular cGMP, and drives ion and fluid secretion. Capa-2 can be used in studies of diuresis.
    Capa-2
  • HY-P11382
    Octadecaneuropeptide 95237-86-8 98%
    Octadecaneuropeptide is an 18-residue peptide. Octadecaneuropeptide can be derived from Diazepam binding inhibitor. Octadecaneuropeptide includes a specific ligand for the gamma-aminobutyric acid receptor regulatory site occupied by beta-carbolines. Octadecaneuropeptide elicits a dose-related facilitation of the punishment- elicited suppression of drinking.
    Octadecaneuropeptide
  • HY-P11389
    (Sar1,Gly8)-Angiotensin II 51887-62-8 98%
    (Sar1,Gly8)-Angiotensin II is an AT1 angiotensin II receptor subtype selective antagonist (Ki: 52 nM for AT2 receptor in rat adrenal). (Sar1,Gly8)-Angiotensin II potently antagonizes dipsogenic responses to intracerebroventricularly administered Ang II.
    (Sar1,Gly8)-Angiotensin II
  • HY-P11405
    [D-Arg1,D-Trp5,7,9,Leu11]-Substance P 122481-75-8 98%
    [D-Arg1, D-Trp5, 7, 9, Leu11]-Substance P is a potent inhibitor of cell growth in small cell lung cancer (SCLC). [D-Arg1, D-Trp5, 7, 9, Leu11]-Substance P is also a neuropeptide antagonist, capable of blocking colony formation stimulated by various neuropeptides (including vasopressin and bradykinin). [D-Arg1, D-Trp5, 7, 9, Leu11]-Substance P inhibits the mobilization of Ca2+ and the activation of mitogen-activated protein kinases induced by vasopressin or bradykinin. [D-Arg1, D-Trp5, 7, 9, Leu11]-Substance P inhibits the growth of H-69 xenograft tumors in nude mice.
    [D-Arg1,D-Trp5,7,9,Leu11]-Substance P
  • HY-P11408
    [D-Cys6,Asn7,D-Ala11,Cys14]-Bombesin (6-14) 349657-39-2
    [D-Cys6,Asn7,D-Ala11,Cys14]-Bombesin (6-14), a synthetic peptide, is a non-selective bombesin receptor agonist. [D-Cys6,Asn7,D-Ala11,Cys14]-Bombesin (6-14) has preferred pEC50 values of 8.06 for the neurotrophin B bombesin receptor (BB1), 8.69 for the gastrin-releasing peptide bombesin receptor (BB2), and 6.71 for the orphan receptor (BB3). [D-Cys6,Asn7,D-Ala11,Cys14]-Bombesin (6-14) can be used to study diseases related to bombesin receptors, such as cancer and neurological disorders.
    [D-Cys6,Asn7,D-Ala11,Cys14]-Bombesin (6-14)
  • HY-P11409
    Prion Protein (118-135), human 202121-03-7
    Prion Protein (118-135), human is the 118-135 fragment of human prion protein. Prion Protein (118-135), human induces Apoptosis. Prion Protein (118-135), human stimulates caspase-3 and -9 activities. Prion Protein (118-135), human is cytotoxic to retinal neurons. Prion Protein (118-135), human exerts neurotoxic effects.
    Prion Protein (118-135), human
  • HY-P11414
    Cys-flag peptide 1165821-46-4
    Cys-flag peptide (CDYKDDDDK) is a FLAG tag peptide containing cysteine. Cys-flag peptide has a targeted interaction for protein purification and detection. Cys-flag peptide can be used for the research of neurological disease, such as Alzheimer’s disease.
    Cys-flag peptide
  • HY-P11419
    Metamorphosin A 157622-03-2 98%
    Metamorphosin A is a neuropeptide that can be isolated from Anthopleura elegantissima. Metamorphosin A triggers metamorphosis in Hydractinia echinata.
    Metamorphosin A
  • HY-P11431
    Cyclo(Gly-Pro) 97011-16-0 98%
    Cyclo(Gly-Pro) is a cyclic dipeptide. Cyclo(Gly-Pro) can be derived from the Nterminus of the IGF-1. Cyclo(Gly-Pro) attenuates nociceptive behaviour and inflammatory response in mice.
    Cyclo(Gly-Pro)
  • HY-P11432
    PG-911 98%
    PG-911 is a full MC5R agonist (EC50 = 0.031 nM for hMC5R). PG-911 is also a full antagonist at the hMC3R and the hMC4R (Kb: 0.38 nM and 0.17 nM, respectively). PG-911 can be used in the research of neurological disorders.
    PG-911
  • HY-P11461
    Biotin-CRF, human, rat 105883-79-2
    Biotin-CRF, human, rat is a biotin-conjugated CRF (human, rat). CRF (human, rat) is a corticotropin-releasing hormone, paraventricular hypothalamic nucleus marker.
    Biotin-CRF, human, rat
  • HY-P11496
    CK2 Substrate peptide 154444-98-1
    CK2 Substrate peptide (Compound RRRADDSDDDDD) is a specific CK2 peptide substrate with Km of 13 μM. CK2 Substrate peptide can be used for the research of neurological disease, such as Alzheimer's Disease.
    CK2 Substrate peptide
  • HY-P11581
    MNP2 98%
    MNP2 is a NLRP3-ASC interaction inhibitor. MNP2 selectively binds to the PYD domain of ASC (Ka=149 nM) and blocks ASC-PYM binding (Ka=58 nM), thereby inhibiting the interaction between ASC and NLRP3 and suppressing the formation of the NLRP3 inflammasome. MNP2 inhibits IL-1β release and caspase-1 maturation, and reduces the efflux of potassium and chloride ions. MNP2 prevents mitochondrial damage and reactive oxygen species production, and significantly decreases NLRP3 inflammasome formation in neurodegenerative pathologies induced by β-amyloid, Tau protein and α-synuclein. MNP2 is applicable for the research of neurodegenerative diseases.
    MNP2
  • HY-P11593
    D-TLKIVWC 3105302-84-6
    D-TLKIVWC is a tau fibril disaggregator. D-TLKIVWC has low immunogenicity and anti-degradation properties. D-TLKIVWC disrupts intermolecular hydrogen bonds of tau via a stress-release mechanism. D-TLKIVWC can be used in the research of amyloid diseases such as Alzheimer's disease.
    D-TLKIVWC
  • HY-P11605
    Big endothelin-3 (Human, 1-41 amide) 133551-97-0
    Big endothelin-3 (Human, 1-41 amide) is a precursor molecule of the Endothelin-3 (ET-3) peptide composing of 41 amino acids.
    Big endothelin-3 (Human, 1-41 amide)
Cat. No. Product Name / Synonyms Application Reactivity